Working Memory in Schizophrenia as Revealed by Event-Related Potentials-Reference-Cited by-同舟云学术

Working Memory in Schizophrenia as Revealed by Event-Related Potentials

Published:2001-02 Issue:1 Volume:12 Page:26-31
ISSN:1016-264X
Container-title:Zeitschrift für Neuropsychologie
language:de
Short-container-title:Zeitschrift für Neuropsychologie

Author:

Brand Andreas¹,Hildebrandt Helmut²,Cabuk Ahmet³,Zimmermann Jörg⁴,Basar-Eroglu Canan³

Affiliation:

1. Center for Psychiatry and Psychotherapy, General Hospital Bremen-Ost, Bremen, Institute of Psychology and Cognitive Research, University of Bremen, Bremen, Hanse Institute for Advanced Study, Delmenhorst, Germany

2. Center for Psychiatry and Psychotherapy, General Hospital Bremen-Ost, Bremen, Program of Neuropsychology, University of Oldenburg, Oldenburg, Germany

3. Institute of Psychology and Cognitive Research, University of Bremen, Bremen, Germany

4. Center for Psychiatry and Psychotherapy, General Hospital Bremen-Ost, Bremen, Germany

Abstract

Abstract: In this study, we compared working memory (WM) functions for simple actions of healthy subjects and schizophrenic patients by means of behavioral and ERP measures. Healthy subjects showed a large frontal N2 amplitude in the hard WM task with updating demands of temporal sequence, but not in the easy WM and the control task. Schizophrenic patients had large frontal N2 amplitudes in all tasks without difference indicating that the patients had to activate the frontal cortex in tasks in which healthy subjects use automatized routines which do not involve the frontal cortex. Strong negative symptoms in schizophrenic patients were associated with small N2 amplitudes thus supporting the hypothesis of joint causes of cognitive and psychopathological features.

Publisher

Hogrefe Publishing Group

Subject

Psychiatry and Mental health,Cognitive Neuroscience,Neuropsychology and Physiological Psychology

Reference19 articles.

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2. Andreasen, N.C. (1985). Comprehensive assessment of symptoms and history (CASH).. Iowa City, IA: The University of Iowa.

3. Symptoms of Schizophrenia

4. Andreasen, N.C., Swayze, V.W., Flaum, M., O'Leary, D.S., Alliger, R. (1994). The neural mechanisms of mental phenomena. In N.C. Andreasen & A.H. Woods (Eds.), Schizophrenia: From mind to molecule (pp.49-93). Washington, DC: American Psychiatric Press.

5. Brand, A., Hildebrandt, H., Cabuk, A., Basar-Eroglu, C. (submitted). Event-related potentials in sensorimotor working memory.

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