High Dose Pomegranate Extract Suppresses Neutrophil Myeloperoxidase and Induces Oxidative Stress in a Rat Model of Sepsis

Author:

Tavasoli Sanaz12,Eghtesadi Shahryar23,Vafa Mohamadreza3,Moradi-Lakeh Maziar4,Sadeghipour Alireza5,Zarnani Amir-Hassan67

Affiliation:

1. Research Institute for Islamic & Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran

2. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

3. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

4. Department of Community Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

5. Department of pathology, Rasoul-Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran

6. Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

7. Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran

Abstract

Abstract. Introduction: The effect of using high dose pomegranate extract on sepsis and its safety is not clarified. Considering the fact that proper immune and inflammatory responses are needed to cope with infection, the aim of current study was to assess the effect of high dose pomegranate extract consumption on oxidative and inflammatory responses after disease induction in rat model of sepsis. Methods: Sepsis was induced by Cecal Ligation and Perforation (CLP) surgery. Adult male Wistar rats were divided into three groups of eight animals: Sham; CLP and POMx [consumed POMx (250 mg of pomegranate fruit extract/kg/day) for four weeks before CLP]. Results: Peritoneal neutrophil myeloperoxidase activity was significantly lower in POMx compared with Sham and CLP groups ( p < 0.01 and p < 0.05, respectively). Although antioxidant enzymes were higher in POMx group after sepsis induction, lower serum total antioxidant status (TAS) (p < 0.01 compared with both CLP and Sham groups) and higher liver thiobarbituric acid reactive species (TBARS) levels were observed in this group ( p < 0.01 and p < 0.05, compared with Sham and CLP groups, respectively). Conclusion: High dose POMx consumption prior to sepsis induction, suppressed the vital function of neutrophils in early hours after sepsis initiation, resulting in higher oxidative stress. These findings indicate that caution should be made in using high dose pomegranate products. The main message of current study is that such useful compounds as antioxidants including pomegranate juice which have beneficial effects on general health status may have detrimental effects if misused or used in high doses.

Publisher

Hogrefe Publishing Group

Subject

Nutrition and Dietetics,General Medicine,Endocrinology, Diabetes and Metabolism,Medicine (miscellaneous)

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