Affiliation:
1. Division of Sports Physiology, Department of Physiology, Faculty of Medicine, Selçuk University, Konya, Turkey
Abstract
Aim: The purpose of this study was to investigate the effects of curcumin on eccentric exercise-induced muscle damage and oxidative stress in rats. Methods: Thirty male Wistar rats were divided into four groups: Control (C; no curcumin, no exercise; n = 6), Curcumin (Cur; n = 8), Exercise (E; n = 8) and Exercise Plus Curcumin (ECur; n = 8). Curcumin was given for 20 days via oral gavage at doses of 200 mg/kg-1 of body weight per day, dissolved in corn oil. On the 21st day eccentric exercise was provided via a treadmill run and the rats were sacrificed immediately after. Results: Eccentric exercise resulted in significant (p < 0.05) increases in all injury markers such as creatine kinase (CK) and myoglobin, but curcumin supplementation tended to decrease CK activity (p > 0.05) and significantly decreased myoglobin levels (p < 0.05). In blood and muscle samples, malondialdehyde (MDA) levels were not affected by either curcumin or exercise (p > 0.05). MDA levels in liver tissue decreased in the ECur group, compared to the control (p < 0.05). Superoxide dismutase (SOD) activities and glutathione (GSH) levels were affected by neither curcumin nor exercise (p > 0.05), in blood, muscle and liver tissues. Conclusion: The results of this study suggest that curcumin has a protective effect on eccentric exercise induced muscle damage, and that this effect might be independent of oxidative stress and antioxidant systems.
Subject
Nutrition and Dietetics,General Medicine,Endocrinology, Diabetes and Metabolism,Medicine (miscellaneous)
Cited by
13 articles.
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