Changes in rat lens proteins and glutathione reductase activity with advancing age-Reference-Cited by-同舟云学术

Changes in rat lens proteins and glutathione reductase activity with advancing age

Published:2004-09-01 Issue:5 Volume:74 Page:329-333
ISSN:0300-9831
Container-title:International Journal for Vitamin and Nutrition Research
language:en
Short-container-title:International Journal for Vitamin and Nutrition Research

Author:

Katakura ¹,Kishida ²,Hirano ³

Affiliation:

1. Department of Biochemistry, School of Medicine, Iwate Medical University and Division of Basic Science, Iwate College of Nursing

2. Department of Biochemistry, School of Medicine, Iwate Medical University

3. Department of Chemistry, School of Liberal Art and Sciences, Iwate Medical University

Abstract

We examined the changes in the amounts of water-soluble and water-insoluble proteins of rat lenses, and in glutathione reductase activity and glutathione reductase gene expression, with advancing age. The lens total protein increased in 1-month-old rats, 3-month-old rats, and 6-month-old rats, but thereafter decreased in 12-month-old-rats. The water-soluble proteins decreased with advancing age, while the water-insoluble proteins increased. The glutathione reductase activity decreased with advancing age, but the decreased glutathione reductase activity almost recovered by addition of flavin adenine dinucleotide (FAD) in vitro. However, advancing age had no effect on the level of mRNA for glutathione reductase.

Publisher

Hogrefe Publishing Group

Subject

Nutrition and Dietetics,General Medicine,Endocrinology, Diabetes and Metabolism,Medicine (miscellaneous)

Link

https://econtent.hogrefe.com/doi/pdf/10.1024/0300-9831.74.5.329

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