Effects of dietary nitrate and vitamin C co-ingestion on blood pressure and hand-grip strength in young adults

Author:

Lbban Eazaz12ORCID,Macey Alex1,Rundle Joshua1,Ashor Ammar3,Idris Iskandar4ORCID,Siervo Mario156ORCID

Affiliation:

1. School of Life Sciences, The University of Nottingham Medical School, Queen’s Medical Centre, Nottingham, UK

2. Department of Physiology, College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia

3. College of Medicine, University of Al-Mustansiriyah, Baghdad, Iraq

4. School of Medicine, The University of Nottingham Medical School, Derby Hospital, UK

5. School of Population Health, Curtin University, Perth, Australia

6. Dementia Centre of Excellence, enAble Institute, Curtin University, Perth, Australia

Abstract

Abstract: Background: Co-administration of vitamin C and inorganic nitrate ([Formula: see text]) may reduce oxidative stress, boost the conversion of nitrite ([Formula: see text]) into NO and elicit positive vascular effects. Aims: We aimed to test the effects of oral inorganic [Formula: see text] and vitamin C co-supplementation on vascular function, muscular strength, and on concentrations of urinary [Formula: see text], vitamin C, 8-isoprostanes and salivary [Formula: see text] in healthy young adults. Methods: Ten young healthy participants were enrolled in a randomised, double-blind (only for the [Formula: see text] intervention) crossover clinical trial. Participants consumed in random order: 1) nitrate-rich beetroot juice and vitamin C (N+VC), 2) nitrate-rich beetroot juice alone (N) or 3) nitrate-depleted beetroot juice alone (ND). Resting blood pressure (BP) was measured at the research centre and at home. Non-invasive, continuous measurements of BP and cardiac function parameters were performed using a Finometer device. Free-living physical activity and hand-grip strength were assessed. Salivary [Formula: see text] and [Formula: see text] and urinary [Formula: see text], 8-isoprostanes and vitamin C concentrations were measured. Results: There were no significant differences for any of the vascular outcomes between the three interventions groups. However, analyses of within-intervention changes showed a significant lower daily systolic BP in the [Formula: see text]+vitamin C (N+VC) group only (P=0.04). Urinary [Formula: see text] (P=0.002) and salivary [Formula: see text] (P=0.001) were significantly higher in the N+VC group compared to the N and ND groups. Conclusion: These preliminary findings suggest that combining dietary [Formula: see text] with vitamin C could have protective effects on vascular function in young adults and could represent an effective strategy for the maintenance of healthy cardiovascular trajectories.

Publisher

Hogrefe Publishing Group

Subject

Nutrition and Dietetics,General Medicine,Endocrinology, Diabetes and Metabolism,Medicine (miscellaneous)

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