Affiliation:
1. Muhammadiyah University of Yogyakarta
2. Gadjah Mada University
Abstract
Objectives: To analyze the effect of risedronate hydrogel on enzyme alkaline phosphatase (ALP) and osteoclast/osteoblast ratio during tooth relapse movement
Materials and methods: The research design is experimental with time series. The lower incisors of 75 guinea pigs are distally moved using open coil spring. The guinea pigs were divided into three groups: without risedronate (group A; n = 25); given 250 µmol/L of risedronate hydrogel (group B; n = 25), and given 500 µmol/L of risedronate hydrogel (group C; n = 25). Risedronate were applied intrasulcularly in the mesial part of the gingival sulcus every 3 days. After 14 days of stabilization, the open coil spring was removed (bisphosphonate administration was continued). The relapsed teeth and ALP levels on days 0, 3, 7, 14, and 21 were measured. The osteoclast/osteoblast ratio was measured by hematoxylin and eosin staining. ANOVA test was used to determine the difference in the three groups and their interactions with concentration and time.
Results: There was a significant difference in osteoclast/osteoblast ratio on day 3 (p = 0.019, p
Reference32 articles.
1. 1. Littlewood SJ, Kandasamy S, Huang G. Retention and relapse in clinical practice. Aust Dent J 2017; 62:51–7
2. 2. Vaida L, Todor BI, Lile IE, Mut A-M, Mihaiu A, Todor L. Contention following the orthodontic treatment and prevalence of relapse. HMV Bioflux 2019;11:37-42
3. 3. Franzen TJ, Brudvik P, Vandevska-Radunoviv V. Periodontal tissue reaction during orthodontic relapse in rat molars. Eur J Orthod 2013;35:152-9
4. 4. Schneider DA, Smith SM, Campbell C, Hayami T, Kapila S, Hatch NE. Locally limited inhibition of bone resorption and orthodontic relapse by recombinant osteoprotegerin protein. Orthod Craniofac Res 2015;18:187-95
5. 5. Zhao N, Lin J, Kanzaki H, Ni J, Chen Z, Liang W, et al. Local osteoprotegerin gene transfer inhibits relapse of orthodontic tooth movement. Am J Orthod Dentofacial Orthop 2012;141:30-40
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献