Potential inhibitory activities of phytoconstituents in Salvia miltiorrhiza against coronary heart disease drug targets using docking and ADMET studies-Reference-Cited by-同舟云学术

Potential inhibitory activities of phytoconstituents in Salvia miltiorrhiza against coronary heart disease drug targets using docking and ADMET studies

Published:2024-03-01 Issue: Volume: Page:
ISSN:2815-5874
Container-title:Vietnam Journal of Science and Technology
language:
Short-container-title:Vietnam J. Sci. Technol.

Author:

Man Thi Thuy Duong,Nguyen Ngoc Long,Pham Hai Son,Tran Thi Hoai Van,Bach Long Giang,Long Pham Quoc,Ha Viet Hai,Do Tien Lam,Pham Thi Hong Minh,Lê Thị Thùy Hương

Abstract

Coronary heart disease (CHD) is one of the leading causes of death worldwide. The effectiveness of the current drugs is still restricted due to high side effects; thus, it is urgently needed to discover novel compounds for drug development. In the field of drug discovery research, the main target receptors for chemotherapy are identified as ACE, PPAR-γ, HMGR, COX-2, and thrombin. In this study, docking simulations were performed for phytoconstituents of Salvia miltiorrhiza Bunge in searching for compounds with potential inhibitory activities against these proteins. As a result, six compounds were suggested as potential multitarget inhibitors and could be considered for further drug development studies based on docking conformation and ADMET property analysis.

Publisher

Publishing House for Science and Technology, Vietnam Academy of Science and Technology (Publications)

Reference30 articles.

1. Gaziano T. A., Bitton A., Anand S., Abrahams-Gessel S. and Murphy A. - Growing Epidemic of Coronary Heart Disease in Low- and Middle-Income Countries, Curr. Probl. Cardiol. 35 (2) (2010) 72-115. https://doi.org/10.1016/j.cpcardiol.2009.10.002.

2. Sanchis-Gomar F., Perez-Quilis C., Leischik R. and Lucia A. - Epidemiology of coronary heart disease and acute coronary syndrome, Ann. Transl. Med. 4 (13) (2016) 256-256. https://doi.org/10.21037/atm.2016.06.33.

3. Kandaswamy E. and Zuo L. - Recent Advances in Treatment of Coronary Artery Disease: Role of Science and Technology, Int. J. Mol. Sci. 19 (2) (2018). https://doi.org/10.3390/ijms19020424.

4. Elisaf M. - The Treatment of Coronary Heart Disease: An Update, Curr. Med. Res. Opin. 17 (1) (2008) 18-26. https://doi.org/10.1185/0300799039117021.

5. Le D., Brown L., Malik K. and Murakami S. - Two Opposing Functions of Angiotensin-Converting Enzyme (ACE) That Links Hypertension, Dementia, and Aging, Int. J. Mol. Sci. 22 (24) (2021). https://doi.org/10.3390/ijms222413178.