BIODEGRADABLE GELATIN DECORATED Fe3O4 NANOPARTICLES FOR PACLITAXEL DELIVERY

Abstract

The objective of this study is to prepare biodegradable iron oxide nanoparticles with gelatin (GEL) for paclitaxel (PTX) delivery. In detail, Fe3O4 nanoparticles were prepared and then coated them with GEL (Fe3O4@GEL) conjugate by co–precipitation method. Furthermore, the formation of Fe3O4@GEL was demonstrated by Fourier transform infrared (FT–IR) and powder X–ray diffraction (XRD). The superparamagnetic property of Fe3O4@GEL was also showed by hysteresis loop analysis, the saturation magnetization reached 20.36 emu.g–1. In addition, size and morphology of Fe3O4@GEL nanoparticles were determined by transmission electron microscopy (TEM). The results indicated that Fe3O4@GEL nanoparticles were spherical shape with average diameter of 10 nm. Especially, PTX was effectively loaded into the coated magnetic nanoparticles, 86.7 ± 3.2 % for drug loading efficiency and slowly released up to 5 days. These results suggest that the potential applications of Fe3O4@GEL nanoparticles in the development of stable drug delivery systems for cancer therapy.