Influence of the difluoromethylene group (CF2) on the conformation and properties of selected organic compounds

Author:

O'Hagan David1,Wang Yi1,Skibinski Maciej1,Slawin Alexandra M. Z.1

Affiliation:

1. 1EaStCHEM School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK

Abstract

The CF2 group has found applications as a substituent in all classes of organic chemical products from medicinal products to materials, although it is less frequently encountered than the C–F and CF3 substituents. In this review, the geometric influence of placing two fluorine atoms on carbon is considered and in particular, deviations from tetrahedral geometry are noted. The incorporation of the CF2 group into CF2 phosphonates as phosphate mimics is reviewed and the geometric and steric influences of the CF2 group are considered when the substituent is placed within aliphatic chains and aliphatic ring (cyclododecane) systems.

Publisher

Walter de Gruyter GmbH

Subject

General Chemical Engineering,General Chemistry

Reference24 articles.

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4. a;Wiberg;Am Chem Soc,1993

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