Affiliation:
1. 1Zydus Research Center, Moraiya, Ahmedabad 382 210, India
Abstract
Several substituted α-alkoxy phenyl propionic acids were synthesized, and their hypotriglyceridemic properties were evaluated in Swiss albino mice. Some of the compounds showed excellent triglyceride- and cholesterol-lowering properties even at a dose of 1 mg/kg. 2,5-Substituted pyrrole-containing heterocycles were among the most potent alkoxy propionic acid class of compounds. These compounds also showed excellent antidiabetic activities in animal models.
Subject
General Chemical Engineering,General Chemistry
Reference1 articles.
1. cited therein and Novel pyrrole - containing hypoglycemic and hypotriglyceridemic compounds WO patent;Lohray;Med Chem Pure Applied Chemistry,2001