Paclitaxel-albumin interaction in view of molecular engineering of polymer-drug conjugates-Reference-Cited by-同舟云学术

Paclitaxel-albumin interaction in view of molecular engineering of polymer-drug conjugates

Published:2009-01-01 Issue:3 Volume:81 Page:439-450
ISSN:1365-3075
Container-title:Pure and Applied Chemistry
language:
Short-container-title:

Author:

Hess Michael¹,Jo Byung-Wook¹,Wunderlich Stefan²

Affiliation:

1. 1Department of Polymer Engineering and Science, Chosun University, Gwangju, Republic of Korea

2. 3Physical Chemistry, University of Duisburg-Essen, 45117 Essen, Germany

Abstract

The interaction of water-soluble polymer conjugates of the anticancer agent paclitaxel and albumin as model protein has been investigated using fluorescence spectroscopy and NMR. Drugs and drug conjugates can enter the hydrophobic core of albumin; the kinetics of the interaction with the fluorophore, however, differs. Given the information about the steric situation of the formed complexes, some aspects of molecular engineering of the drug are discussed.

Publisher

Walter de Gruyter GmbH

Subject

General Chemical Engineering,General Chemistry

Link

https://www.degruyter.com/downloadpdf/journals/pac/81/3/article-p439.xml

Reference34 articles.

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2. Patent;Greenwald,1999

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