Author:
Fülöp F.,Lázár László,Szakonyi Z.,Pihlavisto M.,Alaranta Sakari,Vainio P. J.,Juhakoski Auni,Marjamäki Anne,Smith D. J.
Abstract
We have synthesized a series of novel hydrazines and hydrazino alcohols that specifically inhibit vascular adhesion protein-1 (VAP-1), a human endothelial cell adhesion molecule with a well documented role in inflammation. VAP-1 is a semicarbazide-sensitive amine oxidase (SSAO), and the enzyme activity has been demonstrated to have a role in VAP-1 function. An indane hydrazino alcohol was able to reduce clinical symptoms of inflammation in experimental arthritis in rodents and has the potential to be a novel anti-inflammatory drug.
Subject
General Chemical Engineering,General Chemistry
Cited by
12 articles.
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