Glossary of terms used in biomolecular screening (IUPAC Recommendations 2011)

Author:

Proudfoot John1,Nosjean Olivier2,Blanchard Jan3,Wang John4,Besson Dominique5,Crankshaw Denis6,Gauglitz Günter7,Hertzberg Robert8,Homon Carol9,Llewellyn Lyndon10,Neubig Richard11,Walker Larry12,Villa Pascal13

Affiliation:

1. 1Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, USA

2. 2Servier Research Institute, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France

3. 3McMaster HTS Laboratory, Department of Biochemistry and Biomedical Sciences, McMaster University, HSC 4N45-D, 1200 Main St. West, Hamilton, ON L8N 3Z5, Canada

4. 4AJLW Consulting, Inc., 649 Via Rialto, Oakland, CA 94619, USA

5. 5World Health Organization, TDR, Special Programme for Research and Training for Neglected Disease, 20 Avenue Appia, 1211 Geneva, Switzerland

6. 6Department of Obstetrics and Gynecology, McMaster University, HSC 3N52, 1200 Main St. West, Hamilton, ON L8N 3Z5, Canada

7. 7Institut für Physikalische und Theoretische Chemie, Universität Tübingen, Auf der Morgenstelle 8, D-72076 Tübingen, Germany

8. 8GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA 19406, USA

9. 9Boehringer Ingelheim Pharmaceuticals, Inc. (retired)

10. 10Australian Institute of Marine Science, PMB 3, Townsville 4810, Australia

11. 11Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-1055, USA

12. 12National Center for Natural Products Research, The University of Mississippi, P.O. Box 1848, University, MS 38677, USA

13. 13IFR 85 “Biomolécules et Innovations Thérapeutiques” 74 Route du Rhin BP 60024, 67401 Illkirch, France

Abstract

Biomolecular screening is now a crucial component of the drug discovery process, and this glossary will be of use to practitioners in the field of screening and to those who interact with the screening community. The glossary contains definitions related to various aspects of the screening process such as assay types, data handling, and relevant technologies. Many of the terms used in this discipline are not covered by existing glossaries, and where they are, the definitions are often not appropriate for this field. Where appropriate, this document provides new or modified definitions to better reflect the new context. The field of biomolecular screening is multidisciplinary in nature, and this glossary, containing authoritative definitions, will be useful not only for regular practitioners, but also for those who make use of data generated during the screening process.

Publisher

Walter de Gruyter GmbH

Subject

General Chemical Engineering,General Chemistry

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