Affiliation:
1. Georgia State University, Atlanta, GA, USA
Abstract
The COVID-19 pandemic has affected millions of people worldwide. While the virus primarily targets the respiratory system, it also affects other organs in the body, leading to multiple organ dysfunction syndrome (MODS) and death. Recent studies have shown that angiotensin-converting enzyme 2 (ACE2) plays a crucial role in pathogenesis of COVID-19 and development of MODS.<br />
Since its discovery in 2000, ACE2 has garnered widespread attention for its multiple physiological roles, leading to subsequent interest in the influence of the Renin-angiotensin system (RAS) on SARS-CoV-2 infection and COVID-19 during the pandemic.<br />
ACE2 is both an enzyme and a functional receptor on cell surfaces through which SARS-CoV-2 enters the host cells. Recent research has highlighted the multifaceted impact of the virus on various organs, showcasing its ability to induce severe multi-organ injuries. Understanding the intricate interplay between ACE2, RAS, and the pathophysiological changes associated with COVID-19 is crucial for the development of effective treatment strategies and preventative measures.<br />
This study investigates the differences in causes of death related to COVID-19 and its complications. Data from cumulative records for all age groups across the 50 states of the USA and the District of Columbia was retrospectively analyzed. The results revealed significant differences in the incidence of COVID-19 deaths associated with various medical conditions, with respiratory complications showing notably higher incidence compared to other medical conditions besides COVID-19, circulatory, and diabetes.
Reference21 articles.
1. Centers for Disease Control and Prevention. Conditions contributing to COVID-19 deaths, by state and age, provisional 2020-2023. Available at: https://data.cdc.gov/NCHS/Conditions-Contributing-to-COVID-19-Deaths-by-Stat/hk9y-quqm (Accessed: 21 November 2023).
2. Elezkurtaj S, Greuel S, Ihlow J, et al. Causes of death and comorbidities in hospitalized patients with COVID-19. Sci Rep. 2021;11(1):4263. https://doi.org/10.1038/s41598-021-82862-5 PMid:33608563 PMCid:PMC7895917
3. Bhaskaran K, Bacon S, Evans SJ, et al. Factors associated with deaths due to COVID-19 versus other causes: Population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform. Lancet Reg Health Eur. 2021; 6:100109. https://doi.org/10.1016/j.lanepe.2021.100109 PMid:33997835 PMCid:PMC8106239
4. Bland JM, Altman DG. Multiple significance tests: The Bonferroni method. BMJ. 1995;310(6973):170. https://doi.org/10.1136/bmj.310.6973.170 PMid:7833759 PMCid:PMC2548561
5. Liang W, Liang H, Ou L, et al. Development and validation of a clinical risk score to predict the occurrence of critical illness in hospitalized patients with COVID-19. JAMA Intern Med. 2020;180(8):1081-9. https://doi.org/10.1001/jamainternmed.2020.2033 PMid:32396163 PMCid:PMC7218676