HYGIENIC CHARACTERISTICS OF ETHANOL FOR PREVENTIVE ANTISEPTICS OF SKIN-Reference-Cited by-同舟云学术

HYGIENIC CHARACTERISTICS OF ETHANOL FOR PREVENTIVE ANTISEPTICS OF SKIN

Published:2024-01-30 Issue: Volume: Page:
ISSN:2618-754X
Container-title:Science and Innovations in Medicine
language:
Short-container-title:Science and Innovations in Medicine

Author:

Gorbachev Dmitrii^ORCID

Abstract

The purpose of this work was to study the chemical and analytical quality indicators, toxicological safety indicators and microbial indicators of the effectiveness of ethyl alcohol 70% of the Lux brand and determine its purpose for skin antisepsis. Material and methods: the studies were performed by organoleptic, physical and chemical, toxicological and microbial methods in accordance with standard modern methods. Results: ethyl alcohol 70% is characterized by chemical and analytical and microbial quality indicators that meet the requirements of the State Pharmacopeia of the Republic of Belarus. According to toxicological indicators, it belongs to class IV substances are low-hazard, with no irritating effect, which corresponds to the regulatory toxicological indicators of the safety of skin antiseptics. During the primary percutaneous application on volunteers, it does not cause subjective and objective symptoms of sensitization; it belongs to substances that do not have an irritating effect and sensitizing ability. Standard test cultures and clinical strains of microorganisms are highly sensitive to ethyl alcohol 70% in a qualitative suspension test tube and micromethod without protein load and moderately sensitive in the disk-diffusion method with an exposure of 1 min. In relation to these microorganisms, the antimicrobial activity of ethyl alcohol 70% is above 99.999% and a reduction factor above 5 lg at exposure of 1 min in a quantitative suspension method without a protein load. Ethyl alcohol 70% is also characterized by a high efficiency of disinfection of the skin and E.coli-contaminated skin of volunteers over 99% and a reduction factor above 2 lg and 4 lg, respectively. Conclusion. Ethyl alcohol 70% of the brand "Lux" - a high-quality, toxicologically safe and microbial effective drug can be recommended for skin antisepsis of the injection field (class A), as well as hygienic hand antisepsis (class B) and antiseptic sanitization of the skin in the Republic of Belarus and Russian Federation.

Publisher

FSBEI of Higher Education SamSMU of Ministry of Health of the Russian Federation

Subject

General Medicine

Link

https://innoscience.ru/2500-1388/article/viewFile/375333/pdf

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