A comparative analysis of anti-seizure drugs consumption released for free or with a discount

Abstract

Aim – to conduct a comparative analysis of the structure of consumption of anti-seizure drugs dispensed free of charge or at a discount for the period of 2017-2021 at the regional level. Material and methods. The data was collected from the works of domestic and foreign scientists in the field of preferential drug provision, as well as regulatory and organizational documentation on pharmaceutical activities. Preferential prescriptions issued for the period from 2017 to 2021 in the Orel region were analyzed. The ATC/DDD methodology was used to estimate the consumption. Results. It was revealed that preferential anti-seizure drugs were mainly taken by people aged 40-64 years. In 2017-2018, the consumption of anticonvulsants was higher in women. In 2019-2021, the consumption level was higher in men. Most of the anti-seizure drugs consumers were federal beneficiaries, usually disabled people of group II. The highest value of consumption among the top 5 INNs of antiepileptic drugs during the study period was observed for phenobarbital. The drugs containing valproic acid, topiramate and carbamazepine were characterized by increasing consumption throughout the study period. For benzobarbital, a pattern of consumption stability was revealed. Conclusion. The ATC/DDD analysis of the consumption structure for anti-seizure drugs within the program of subsidized drug provision for the population made it possible to identify the objective data on the dynamics of consumption for various generations. In order to reduce the consumption of drugs with an unfavorable safety profile, it is necessary to conduct training seminars for doctors of the relevant profile.