The content of interleukins 4, 6, 8, 10 in nasal lavage fluid in chronic rhinosinusitis in middle and old age persons

Abstract

Aim – to study the features of local production of IL-4, IL-6, IL-8, IL-10 in middle age and old age persons with chronic rhinosinusitis. Material and methods. The study included patients aged 45 to 90 years with a confirmed diagnosis of "chronic rhinosinusitis" in the acute stage, who gave written informed consent to the study. The scope of the laboratory examination included determination of the cytokines IL-4, IL-6, IL-8, IL-10 concentration in nasal secretions by enzyme immunoassay. Results. The maximum level of IL-4 was registered in younger persons with chronic rhinosinusitis (45–59 years old) compared with older persons. In our study, the maximum content of IL-6 occurred in a group of patients aged 75–90 years, while the cytokine level significantly exceeded IL-6 in a group of healthy age-related patients, which indicates a more pronounced inflammatory reaction in patients of the oldest group with chronic rhinosinusitis. Cytokine levels above 600 pg/ml were found mainly in patients with chronic rhinosinusitis. Patients of group 4 had high IL-10 values going beyond the range of the comparison groups. Conclusion. The maximum level of macrophage-monocytic cytokines (IL-6 and IL-8) and anti-inflammatory IL-10 was determined in nasal lavage fluid in patients with chronic rhinosinusitis aged 75–90 years, the highest detectable values of IL-4 were characteristic of patients aged 45–59 years.