ANIMAL MODELS FOR CCHFV AND BSL-2, BSL-3 SURROGATE MODELS

Abstract

Crimean-Congo hemorrhagic fever virus (CCHFV) is an important tick-borne human pathogen endemic throughout Asia, Africa and Europe. The pathogenic mechanisms of CCHF are poorly understood, largely due to the dehttps://www.uaiasi.ro/revmvis/index_htm_files/Arth of animal models. However, several important animal models have been recently described, including novel murine models and a non-human primate model. This review, we examine the current knowledge of CCHF-mediated pathogenesis and describe how animal models are helping elucidate the molecular and cellular determinants of disease. This information should serve as a reference for those interested in CCHFV animal models and their utility for evaluation of medical countermeasures and in the study of pathogenesis.