Abstract
Recent studies have highlighted that the risks for developing cardiovascular alterations are significantly increased in
patients who previously suffered from Covid-19. This study aims at determining the functional and structural long-term
effects of Covid-19 disease on the cardiovascular system using a specific and original humanized mouse model
recapitulating the endogenous cardiovascular expression of the SARS-CoV-2 main receptor ACE2 (Angiotensin
Converting Enzyme 2). We will focus on studying the systemic and pulmonary vessels and the cardiac tissue to
understand how SARS-CoV-2 infection leads to cardiac and vascular tissue remodelling and function alteration.
Publisher
Universitatea de Ştiinţele Vieţii "Ion Ionescu de la Brad" din Iaşi