A COMPREHENSIVE OVERVIEW ON CHRONO-THERAPEUTICS AND RECENT ADVANCEMENT AS DELIVERY SYSTEM

Abstract

The main purpose of working on the literature review on this special delivery system is to develop and estimate the various dosages forms and techniques to work on the sustained release of drugs that perfectly target the circadian rhythms or cycle of various diseases. ChrDD refers to the method that is widely used to attain the in vivo drug availability to match up with the circadian cycle of the human being to overcome the side effects of the drugs and enhance or optimize the therapeutic effect of the drugs. The circadian rhythms of the human body fluctuate from time to time during the day, as is well-known. So, for the treatment of such diseases, this method is widely used. Nowadays this method is widely accepted by pharmaceutical companies to minimize the dosing frequencies, toxicity, and drug delivery to treat particular diseases that perfectly match the circadian cycle when the symptoms get maximum to worse condition. These drugs are frequently used to treat conditions like cardiovascular disease, asthma, arthritis, ulcers, diabetes, and more that affect circadian rhythms. They offer the patient who is afflicted with these conditions the greatest advantages and facilitate compliance with the dosage form. In any disease, if there is any variation in circadian rhythms, the drug release also varies to overcome the symptoms of the disease.