Synthesis and Biological Activity Studies of Methyl-5-(Hydroxymethyl)-2-Furan Carboxylate and Derivatives-Reference-Cited by-同舟云学术

Synthesis and Biological Activity Studies of Methyl-5-(Hydroxymethyl)-2-Furan Carboxylate and Derivatives

Published:2019-05-14 Issue:3 Volume:35 Page:080-1085
ISSN:0970-020X
Container-title:Oriental Journal of Chemistry
language:
Short-container-title:Orient. J. Chem

Author:

Phutdhawong Weerachai¹,Inpang Siwaporn²,Taechowisan Thongchai³,Phutdhawong Waya S.²^ORCID

Affiliation:

1. Department of Science, Faculty of Liberal Arts and Science, Kasetsart University, Kamphaeng Sean campus,Nakhon Pathom, 73140,

2. Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom 73000, Thailand.

3. Department of Microbiology, Faculty of Science, Silpakorn University, Nakhon Pathom 73000, Thailand.

Abstract

Methyl-5-(hydroxymethyl)-2-furan carboxylate and derivatives were prepared from furfuryl alcohol and their biological activities were studied for cytotoxicity against cancer cell lines HeLa, HepG2 and Vero, and Gram (+) and Gram (-) bacteria. The amine derivative, (5-(((2-(1H-indol-3-yl)ethyl)amino)methyl) furan-2-yl)methyl acetate, was found to have the most potent biological activity with IC50 62.37 µg/mL against the HeLa cell line and MIC 250 µg/mL against the photogenic bacteria.

Publisher

Oriental Scientific Publishing Company

Subject

Drug Discovery,Environmental Chemistry,Biochemistry,General Chemistry

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