Synthesis of some New Azo Compounds of Salicylic Acid Derivatives and Determination of their In vitro Anti-inflammatory Activity-Reference-Cited by-同舟云学术

Synthesis of some New Azo Compounds of Salicylic Acid Derivatives and Determination of their In vitro Anti-inflammatory Activity

Published:2019-04-28 Issue:2 Volume:35 Page:870-876
ISSN:0970-020X
Container-title:Oriental Journal of Chemistry
language:
Short-container-title:Orient. J. Chem

Author:

Hamza Salman Husam¹^ORCID,Salih Abood Huda¹,Hamid Ramadhan Usama²

Affiliation:

1. Department of Pharmaceutical Chemistry, College of Pharmacy, University of Basrah, Iraq.

2. Department of Laboratories Clinical Science, College of Pharmacy, University of Basrah, Iraq.

Abstract

This study included the preparation of a series of some new azo compounds by diazo coupling aromatic amines with salicylic acid derivatives. The prepared compounds identified using precise elemental analysis (C.H.N.), the results supported the structure of concerned compounds. The synthesized azo compounds also identified by using infrared spectroscopy and 1H-NMR spectroscopy. Anti-inflammatory activity of the compounds were determined in-vitro by human red blood cell (HRBC) membrane stability method, the compounds showed a significant activity to protection of the cell membrane. Other compounds show moderate to low activity, sodium diclofenac was used as positive control.

Publisher

Oriental Scientific Publishing Company

Subject

Drug Discovery,Environmental Chemistry,Biochemistry,General Chemistry

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