Ultrasound Synthesis of Benzimidazolo-1,3,5-Triazine Derivatives and Their Anti-Histamine and Anti-Diabetic Activities
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Published:2019-07-19
Issue:4
Volume:35
Page:1368-1376
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ISSN:2231-5039
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Container-title:Oriental Journal Of Chemistry
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language:en
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Short-container-title:Orient. J. Chem
Author:
Aljameel Suhailah S.1, Fataftah Houda M.1, El-Rahman Soheir N. Abd2, Elsharif Asma, M.1, Hafiane A.3, Kamoun Madiha4
Affiliation:
1. Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia. 2. Basic and Applied Scientific Research Center, Imam Abdulrahman Bin Faisal University P.O. Box 1982, 31441, Dammam, Saudi Arabia. 3. Crops Technology Research Department, Food Technology Research Institute, Agricultural Research Center, Giza, Egypt. 4. LEMBE, CERTE BorjCedria, Soliman, 8027, Tunisia.
Abstract
The present work aims to evaluate the anti-diabetic and anti-histamine activity of the synthesized benzimidazolo-1,3,5- triazine derivatives. These newly products have been synthesized under ultrasound irradiation with good yields and their structures were established by spectral data. The amylase inhibition assay and diclorofenac were used to evaluate the antidiabetic and antihistamine of all synthesized derivatives, respectively. It was shown that compounds 3c and 3e give the best of inhibition results of the amylase enzyme with respect to 2-aminobenzimidazole and other derivatives at a concentration of 1000 μg / l, IC 50 = 59.4 and 52.1, respectively. Furthermore, compounds 3e, 3f, 3d, and 3a give highly significant inhibition activity against histamine at various concentrations, IC50 = 25.6, 29.4, 101.9, 121.6, respectively, than compound 3c, 3b, and 2-aminobenzimidazole.
Publisher
Oriental Scientific Publishing Company
Subject
Drug Discovery,Environmental Chemistry,Biochemistry,General Chemistry
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