Triterpenoids from the Bark of Aglaia glabrata and their In vitro Effects on P-388 Murine Leukemia Cells-Reference-Cited by-同舟云学术

Triterpenoids from the Bark of Aglaia glabrata and their In vitro Effects on P-388 Murine Leukemia Cells

Published:2019-01-31 Issue:1 Volume:35 Page:134-139
ISSN:0970-020X
Container-title:Oriental Journal of Chemistry
language:
Short-container-title:Orient. J. Chem

Author:

Harneti Desi¹,Supriadin Asep²,Maharani Rani¹,Nurlelasari Nurlelasari¹,Mayanti Tri¹,Tatang Hidayat Ace¹,Anwar Risyandi³,Supratman Unang¹^ORCID,Awang Khalijah⁴,Shiono Yoshihito⁵

Affiliation:

1. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia.

2. Department of Chemistry, Faculty of Science and Technology, Sunan Gunung Djati Islamic University, Bandung 45262, Indonesia.

3. Department of Pediatric Dentistry, Faculty of Dentistry, Muhammadiyah University, Semarang 50273, Central Java, Indonesia.

4. Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 59100, Malaysia.

5. Department of Food, Life, and Environmental Science, Faculty of Agriculture,Yamagata University, Tsuruoka, Yamagata 997-8555, Japan.

Abstract

Four dammarane-type triterpenoids, dammardienon (1), aglaiabbreviatin E (2), dammar-20,25-dien-3b,24-diol (3) and dammar-24-en-3b,20-diol (4) were isolated from methanolic extract of the bark of Aglaia glabrata. The structures of all triterpenoids were elucidated by 1D-, 2D-NMR, and comparison with previously reported data. All triterpenoids were applied into in vitro bioassay against P-388 murine leukemia cell. Dammar-24-en-3b,20-diol (4) has cytotoxic activity with IC50 value of 9.45 mM towards P-388 murine leukemia cell lines.

Publisher

Oriental Scientific Publishing Company

Subject

Drug Discovery,Environmental Chemistry,Biochemistry,General Chemistry

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