Assessment of Specific and Non-specific Autoantibodies among Newly Diagnosed Type 1 Diabetes Mellitus Sudanese Patients-Reference-Cited by-同舟云学术

Assessment of Specific and Non-specific Autoantibodies among Newly Diagnosed Type 1 Diabetes Mellitus Sudanese Patients

Published:2022-09-29 Issue:3 Volume:15 Page:1477-1482
ISSN:2456-2610
Container-title:Biomedical and Pharmacology Journal
language:en
Short-container-title:Biomed. Pharmacol. J.

Author:

Ishaq Hind Amin¹^ORCID,Ibrahim Mariam Abbas¹^ORCID,Ismail Amar Mohammed²,Abubaker Nuha Eljaili¹^ORCID,M Elfaki Elyasa³

Affiliation:

1. 1Department of Clinical Chemistry, College of Medical Laboratory Science, Sudan University of Science and Technology, Sudan.

2. 2Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, AL-Neelain University, Sudan.

3. 3Department of Clinical Laboratory Sciences, College of Applied Medical Science, Jouf University, Al-Qurayyat, Saudi Arabia.

Abstract

Background: Pathogenesis of type 1 diabetes mellitus is associated with the presence of specific autoantibodies and viral infection. Herein we aim to assess specific and nonspecific autoantibodies in newly diagnosed type 1 diabetes mellitus patients. Materials and Methods: In this case-control study 200 subjects were enrolled, classified into 100 newly diagnosed type 1 diabetes mellitus patients ages ranged from 1 to 16 years old, and 100 apparently health control age matched group. Serum anti-glutamic acid decarboxylase/tyrosine Phosphatase 2 (anti-GAD/IA2), anti-tissue transglutaminase (anti-tTG) and antinuclear antibodies were measured. Results: Of 100, 62(62%) were males, and 38(38%) were females. Anti-GAD/IA2, anti-tTG, and antinuclear antibodies were found to be significantly higher in the case than in the control group. Anti-GAD/IA2 and anti-tTG were associated with higher risk of type 1 diabetes mellitus (OR= 5.44, P= 0.000) and (OR=5.82, P= 0.009) respectively. Conclusion: Anti-GAD/IA2, anti-tTG and antinuclear antibodies are higher in type 1 diabetes mellitus patients. Moreover, anti-GAD/IA2 and anti-tTG are associated with a high risk of type 1 diabetes mellitus.

Publisher

Oriental Scientific Publishing Company

Subject

Pharmacology

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