Molecular and Immunological Mechanisms of Miana Leaf (Coleus Scutellariodes [L] Benth) in Infectious Diseases

Abstract

Infectious disease is still a massive world burden of disease. It causes premature mortality and morbidity. Regardless of antibiotic therapy, the increased numbers of antibiotic resistance bring emerging problems in infectious disease. Several pathogens have unique roles to deactivate host immune response causing difficulty to treat the infection. Alack of antibiotic efficacy is crucial to modulate the immune response as a brilliant strategy to face infectious disease in years to come. Various herbal medicine has been known to have a pivotal role in enhancing immune response at the molecular level. Miana leaves extract (MLE) has a potential role in regulating the immune response to the infection. Besides its antimicrobial effect, MLE has other properties such as anti-inflammation, antioxidant. Several studies have revealedthe molecular mechanism of MLE in immune response, such as enhancing IL 37, IL 10, regulating TLR 4, and IFN-g. The objectives of this article are to review the molecular and immunological mechanism of Miana in treating various infective diseases comprehensively.