Maternal Serum Soluble Endoglin Levels as a biomarker in Preeclampsia: A Case Control Tertiary Care Hospital Based Study

Abstract

Preeclampsia (PE) is a multifactorial pregnancy specific disorder with complexity in pathophysiology. Many markers have been evolved but none of them was specific. The aim of the study was to compare the maternal serum soluble endoglin (sEnd) levels in pre-eclamptic & normotensive pregnant women in early and late gestational weeks. A total of 300 subjects were enrolled from the R.L.Jalappa Hospital and Research Centre, Obstetrics & Gynaecology department. In this case-control study design the cases were 150 subjects who were diagnosed as pre-eclamptic women and controls are 150 normotensive pregnant women who are healthy without any complications till delivery. Both in cases and controls the subjects were after 20 weeks of gestation. By taking written informed consent from each participant the 5ml of blood was collected and measured for the estimation of sEnd levels by using commercially available kits. The Area under Receiver Operating Characteristic Curve was calculated by using Statistical Packages for Social sciences Software with values 0.87 with 87% sensitivity and 83% specificity with cut off value ≥ 8 ng/ml. The sEnd levels are significantly increased in preeclamptic women than normotensive pregnant women (P=0.0001).So sEnd can be a diagnostic marker for PE in Kolar population. This is the first south eastern Indian study with 300 sample size.