Nanoparticles – A Booming Drug Delivery System in Chemotherapy-Reference-Cited by-同舟云学术

Nanoparticles – A Booming Drug Delivery System in Chemotherapy

Published:2023-09-30 Issue:3 Volume:16 Page:1785-1790
ISSN:2456-2610
Container-title:Biomedical and Pharmacology Journal
language:en
Short-container-title:Biomed. Pharmacol. J.

Author:

Verma Shalu¹^ORCID,Singh Alka²^ORCID,Kukreti Gauree²^ORCID,Bharkatiya Meenakshi³^ORCID,Dobhal Kiran⁴^ORCID,Parashar Tarun¹^ORCID,Suyal Jyotsana¹^ORCID,Jakhmola Vikash¹

Affiliation:

1. 1Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand, India

2. 2School of Pharmaceutical Sciences and Technology, Sardar Bhagwan Singh University, Balawala, Dehradun, Uttarakhand, India

3. 3B.N Institute of Pharmaceutical Sciences, B.N University, Udaipur, Rajasthan, India

4. 4College of Pharmacy, Shivalik Campus, Dehradun, Uttarakhand, India

Abstract

The current study proposed the “Nanoparticles -A Booming Drug Delivery System in Chemotherapy” is a Novel targeted approach which enhances the efficacy of chemotherapeutic agents by reducing the dose-related side effect as well as mortality rate a in patients due to its non-immunogenic, nontoxic nature. Drug bioavailability, drug solubility, drug biodistribution, drug resistance brought on by treatment, and nonspecific toxicity can all be improved with the development of nanoparticle chemotherapeutic drug delivery applications based on nanotechnology. It possesses active as well as passive targeting of tumour cells. Due to this reason, a wide range of chemotherapeutic agents like cisplatin, taxol, doxorubicin, and carboplatin are extensively utilized for treating cancer. Deep tissue penetration of nanoparticles is found to increase the enhanced permeability and retention (EPR) effect. There are some limitations with conventional drug delivery system which is minimized by utilizing nanoparticles as a drug delivery system. The current review has focused on targeted strategies and novel approaches in cancer treatment with nanoparticles.

Publisher

Oriental Scientific Publishing Company

Subject

Pharmacology

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