Multi Metal Ion Recognizing Unsymmetrical tetra Dentate Schiff bases associated with Antifungal Activity
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Published:2021-08-30
Issue:4
Volume:37
Page:833-846
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ISSN:2231-5039
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Container-title:Oriental Journal Of Chemistry
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language:en
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Short-container-title:Orient. J. Chem
Author:
Shunmugaperumal Selvaraj1ORCID, Dhasarathan Saranya1ORCID, P Kamatchi Selvaraj.1ORCID, Kaliappan Ilango2ORCID
Affiliation:
1. 1Department of Chemistry, Government Arts College for Men (Autonomous), Nandanam, Chennai-600 035, Tamil Nadu, India. 2. 2Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur-603 203, Chengalpattu District, Tamil Nadu, India.
Abstract
New unsymmetrical Schiff bases containing azomethine moiety with simple aromatic section in one side and ferrocene fragment attached imine on the other side have beensynthesized. Advent of metal-to-ligand charge transfer band for the coordination of Cu2+ ions with receptors and appropriate changes in UV-Visible spectra for other metal ion combination with the sensor is reported. Observed extravagant ΔEpvalues suggest quasi-reversible process. The ΔIpa amount calculated from the anodic current Ipa value noticed for receptor solution and different metal ion added sensor solution discloses the concentration of metal ions required for effective sensing. The synthesized ligands were subjected to antimicrobial activity against four bacterial and two fungal stains and the zone of inhibition (in mm) was calculated. Further molecular docking study was carried out and the binding energy (Kcal.mol-1) for the synthesized ligand (R1 and R2) with the selected protein was intended.
Publisher
Oriental Scientific Publishing Company
Subject
Drug Discovery,Environmental Chemistry,Biochemistry,General Chemistry
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