Synthesis,Characterization, biocidal, Anti-diabetic, Anti-inflammatory and Anti-Cancer(MCF-7) Studies of Schiff base ligand and its metal (II) complexes

Abstract

A new Schiff base ligand (L1) was prepared from 3-aminoquinoline with 2, 5 dimethoxybenzaldehyde in 1:1 molar ratio. Two different co-ordination of mononuclear metal(II) complexes [(ML1) &(ML1L2)] [ M= Co(II), Ni(II), Cu(II) and Zn(II)] were synthesized & characterized. ML1wereprepared from L1 and metal acetate salts molar proportion One:Two. ML1L2 synthesized from L1, metal salts and 8-hydroxy quinoline (L2) molar ratiois 1:1:1. Elemental analyses, IR, NMR, Electronic spectra, Mass spectra, EPR, SEM and Powder XRD &molar conductivity are need to clarify the structure of synthesized metal(II) complexes. The squareplanar geometry is proposed for CuL1, NiL1, ZnL1, NiL1L2 and ZnL1L2, tetrahedral geometry for CoL1&CoL1L2 and distorted square planar geometry for CuL1L2complex. Powder XRD reveals that L1, ML1& ML1L2 have crystalline nature. Antibacterial activity of Ligand,ML1& ML1L2 were screened against bacterium Gram(+), Gram(-) &antifungal activity was determined against fungus. Theanti-inflammatory and anti-diabetic actions of the L1, CuL1 &CuL1L2complexes were studied. Theanticancer activity of L1, CuL1 and CuL1L2 were studied opposed toMCF-7 using MTT assay method.