The Effects of Vitamin B Combination Injection on Lymphocyte Count in Chronic Kidney Failure Patients

Abstract

Background: Chronic kidney failure will lead to decline in immune system. Vitamin B considered has essential roles in immune system, including lymphocyte count. Aims: Measure the effects of vitamin B combination injection on lymphocyte count in chronic kidney failure patients. Methods: This was quasi-experimental study with one group pretest-posttest design from the period of August 2018 - October 2018 at Bethesda Hospital and Panti Rapih Hospital, Yogyakarta, Indonesia. Subjects received vitamin B combination injection (intravenous) after each hemodialysis. Lymphocyte count were measured 3 times namely visit I (before first hemodialysis), visit II (after second hemodialysis), and visit III (after third hemodialysis). Results: The data were obtained from 115 chronic kidney failure patients, consist of 75 male and 40 female. The most common age group in this study was 40-59 years old. There were no significant improvements of lymphocyte counts, both on visit II compared to visit I (1285.713±475.9829/mm3 vs 1504.219±1148.974/mm3; p: 0.065) as well as visit III compared to visit I (1285.713±475.9829/mm3 vs 1315.192±658.6673/mm3; p: 0.766). Conclusion: Vitamin B combination injection has no significant effects on lymphocyte count in chronic kidney failure patients. Intravenous vitamin B was safe for chronic kidney failure patients.