Microwave Synthesis, Characterization and Antimicrobial activity of some Chromene derivatives

Abstract

In the present study the synthesis of Chromene derivatives 7-ethyl-2, 3, 4, 4a-tetrahydro-1H-xanthen-1-one (3a), 7-bromo-2, 3, and 4, 4a-tetrahydro-1 H-xanthen-1-one (3b), 5-ethoxy-2, 3, and 4, 4a-tetrahydro-1 H-xanthen-1-one (3c),7-ethyl-3, 3a-dihydrocyclopenta[b]Chromen-1(2H)-one (4a), 7-bromo-3, 3a-dihydrocyclopenta[b]Chromen-1(2H)-one (4b),and 5-ethoxy-3, 3a-dihydrocyclopenta[b]Chromen-1(2H)-one (4c) have been reported by the reaction of substituted Salicylaldehyde with 2-cyclopenten-1-one/2-cyclohexen-1-one in the presence of ammonium acetate with ethanol using microwave-irradiation. The Microwave synthesized complexes have been categorized via IR, 1H-NMR, 13C-NMR, Mass Spectroscopy then elemental analysis. In this Microwave irradiation method contains two scheme, in the Scheme 2 gives high yield compare to Scheme 1.In the antibacterial and anti-fungal study the compounds 3b, 4a shows good and 4b shows very good activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus and 3b, 3c shows good activity against Aspergillus Niger, Penicillium species and Candida albicans, compare to others. Short reaction time, environmentally friendly products, high economical, excellent yield and good microbial activity are the highest benefits of this technique which create it high commercial than the other methods.