Intermolecular Interaction between Chlorpheniramine and 1-ethanol at Various Temperatures

Author:

Elangovan Sampandam1ORCID,Garbi Tilahun Diriba1ORCID,Thillaiarasu Ponnusamy2ORCID

Affiliation:

1. Department of Physics, College of Natural and Computational Science, Wollega University, Nekemte, Ethiopia-395

2. Department of Chemistry, College of Natural and Computational Science, Wollega University, Nekemte, Ethiopia-395

Abstract

Density (ρ), viscosity (η) and ultrasonic velocity (U) of chlorpheniramine with 1-ethanol mixtures are measured in a range of temperatures 303K, 308K and 313K. By using the systematic measurements, various physico chemical quantities, adiabatic compressibility (β), free length (Lf), free volume (Vf), viscous relaxation time (τ) and Gibbs free energy (ΔG) are attained. The deviations of those quantities to their ideal values are derived and revealed with the intermolecular interactions. The standard deviations and the coefficients of Redlich Kister polynomials of excess quantities are also determined to validate the calculations. From these observations, the existence of intermolecular interaction is confirmed and the strength of interactions with the temperatures as 303K>308K>313 K.

Publisher

Oriental Scientific Publishing Company

Subject

Pharmacology (medical),Complementary and alternative medicine,Pharmaceutical Science

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