Antihyperglycemic Avtivity of Plumeria alba Linn. Leaves Extracts in Streptozotocin-nicotinamide Induced Diabetic Rats
-
Published:2023-03-21
Issue:1
Volume:16
Page:567-571
-
ISSN:2456-2610
-
Container-title:Biomedical and Pharmacology Journal
-
language:en
-
Short-container-title:Biomed. Pharmacol. J.
Author:
Nanda Jyoti1, Mani Munesh1ORCID, Mishra Shanti Bhushan2ORCID, Verma Neeraj3ORCID
Affiliation:
1. 1Pharmacy Academy, IFTM University, Moradabad, U.P., India 2. 3United Institute of Pharmacy, Prayagraj, U.P., India 3. 4Hygia Institute of Pharmaceutical Education and Research, Lucknow, U.P., India
Abstract
Diabetes mellitus is a metabolic condition wherein the body's blood sugar levels are elevated. Plant-based treatments are less toxic than allopathic pharmaceuticals. Plumeria alba Linn (Apocynaceae) is a popular medicinal plant that contains flavonoids, tannins, alkaloids, terpenoids, and antioxidants. The antihyperglycemic action of Plumeria alba Linn. leaves, on the other hand, has yet to be determined. A Streptozotocin-nicotinamide-induced Type II diabetes model was used to elaborate on the hypoglycemic activity of ethanolic and aqueous leaf extractives of Plumeria alba, which were compared to the diabetic control group. Anti-diabetic activity was tested on albino Wistar rats. Normal and experimental rats were given ethanolic and aqueous leaf extracts at 250 mg/kg b.w. and 500 mg/kg b.w. for 21 days, and the effect on blood sugar levels was measured. In comparison to the diabetic control group, the ethanolic extract at a dose of 500 mg/kg b.w. exhibits a highly significant (p<0.001) reduction in blood glucose levels.
Publisher
Oriental Scientific Publishing Company
Reference12 articles.
1. 1. Chopra, R. N., Nayar, S. L., Chopra, I. C., & Council of Scientific & Industrial Research (India). (1956). Glossary of Indian medicinal plants,. Council of Scientific & Industrial Research. 2. 2. Dubourg, J., Fouqueray, P., Quinslot, D., Grouin, J.-M., & Kaku, K. (2022). Long-term \’safety and efficacy of imeglimin as monotherapy or in combination with existing antidiabetic agents in Japanese patients with type 2 diabetes (TIMES 2): A 52-week, open-label, multicentre phase 3 trial. Diabetes, Obesity and Metabolism, 24(4), 609–619. https://doi.org/10.1111/dom.14613 3. 3. Global report on diabetes. (2016). https://www.who.int/publications-detail-redirect/9789241565257 4. 4. Gupta, Dr. S., Sharma, H., Morsy, M., Nair, A., Kaur, K., Kumar, S., & Dhanawat, M. (2021). Protective Effect of Plumeria obtusa Leaves Extracts on Dexamethasone-induced Insulin-resistance Diabetes Mellitus in Rats. Indian Journal of Pharmaceutical Education and Research, 55, s184–s192. https://doi.org/10.5530/ijper.55.1s.49 5. 5. Harris, S. T., Patorno, E., Zhuo, M., Kim, S. C., & Paik, J. M. (2021). Prescribing Trends of Antidiabetes Medications in Patients With Type 2 Diabetes and Diabetic Kidney Disease: A Cohort Study. Diabetes Care, 44(10), 2293–2301. https://doi.org/10.2337/dc21-0529
|
|