The Effect of Pumpkin Seed Flour (Cucurbita Moschata) on Blood Pressure of Hypertensive Rats (Rattus novergicus L)-Reference-Cited by-同舟云学术

The Effect of Pumpkin Seed Flour (Cucurbita Moschata) on Blood Pressure of Hypertensive Rats (Rattus novergicus L)

Published:2023-03-21 Issue:1 Volume:16 Page:519-524
ISSN:2456-2610
Container-title:Biomedical and Pharmacology Journal
language:en
Short-container-title:Biomed. Pharmacol. J.

Author:

Fajrani Alya¹,Syam Aminuddin¹,Indriasari Rahayu¹,Hadju Veni¹,Zulkifli Andi²,Zainal Zainal³

Affiliation:

1. 1Department of Nutrition, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia

2. 2Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia

3. 3Department of Agricultural, Faculty of Agriculture, Hasanuddin University, Makassar, South Sulawesi, Indonesia.

Abstract

Hypertension is a medical condition where blood pressure increases over the normal limit. One alternative food with the potential for anti-hypertension is pumpkin seeds (Cucurbita Moschata). This study aims to determine pumpkin seed flour's effect on blood pressure changes in hypertensive rats. This type of study is experimental with a pretest-posttest controlled group design. This study's samples were rats induced by Sodium chloride to be hypertensive. Blood pressure measurement using Non-Invasive Blood Pressure CODA (Tail Cuff) method. The rat was divided into a control group, pumpkin seed flour group 4.5 mg, and pumpkin seed flour group 5.4 mg; the intervention was given for 28 days. The analysis in this study used the one-way ANOVA test. The results showed a significant reduction in blood pressure in the rats found in pumpkin seed flour (p<0.05). There was a significant difference in blood pressure before and after treatment between pumpkin seed flour and the control group with a value (p<0.001). Pumpkin seed flour is effective in reducing the blood pressure of hypertensive rats. This study has the potential to be applied to the human who has hypertension.

Publisher

Oriental Scientific Publishing Company

Subject

Pharmacology

Reference24 articles.

1. 1. WHO. World Health Statistic Report 2015. In: World Health Organization. ; 2015.

2. 2. Kemenkes RI. Hasil Riset Kesehatan Dasar Tahun 2018. Kementrian Kesehat RI. 2019;53(9):1689-1699.

3. 3. Hussaana, Sarosa, Indrayani, Chodidjah, Widiyanto P. Formula Jamu Antihipertensi and captopril are equally effective in patients with hypertension. Universa Med. 2016;35(2):81-88.

4. 4. Cossignani L. Chemical and Nutritional Characterization of Seed Oil from Cucurbita maxima L. (var. Berrettina) Pumpkin. Published online 2018. doi:10.3390/foods7030030

5. 5. Pawarti. Penyalahgunaan Buah Labu Segar (Cucurbita Sp) Menjadi Intermediate Product (Tepung Labu) Sebagai Upaya Menuju Pertumbuhan Inklusif Berkelanjutan Di Wilayah Kabupaten Semarang. Univ Katolik Soegijapranata Semarang. Published online 2012.