An Overview of Synthetic Approaches towards of Nitration of α-Tetralones-Reference-Cited by-同舟云学术

An Overview of Synthetic Approaches towards of Nitration of α-Tetralones

Published:2019-09-19 Issue:3 Volume:16 Page:189-197
ISSN:0973-3469
Container-title:Material Science Research India
language:
Short-container-title:Mat. Sci. Res. India

Author:

Sultan Aeysha¹,Raza Abdul Rauf²,Mehmood Mian Habib Ur Rehman¹,Nisar Bushra³,Rubab Syeda Laila¹,Irfan Ali³,Acevedo Roberto⁴^ORCID

Affiliation:

1. Department of Chemistry, Faculty of Science and Technology, University of Education, Lahore, Pakistan

2. Ibn e Sina Block, Department of Chemistry, University of Sargodha, Sargodha-40100, Pakistan

3. Department of Chemistry, University of Lahore, Sargodha Campus, Sargodha-40100, Pakistan

4. Facultad de Ingeniería y Tecnología. Universidad San Sebastián, Bellavista 7, Santiago 8420524, Chile

Abstract

The 1-tetralone scaffold and its derivatives are not only important as pharmacological agents but these also serve as precursors for natural products and compounds of medicinal importance. The easiest way to introduce a substituent on an aromatic as well as aliphatic system is nitration. Once introduced, the –NO2 group can be easily replaced by a wide range of functional groups. The review aims to highlight strategies for nitration of substituted and unsubstituted 1-tetralone which led to introduction of NO2 functionality at various positions.

Publisher

Oriental Scientific Publishing Company

Subject

Pharmacology (medical),Complementary and alternative medicine,Pharmaceutical Science

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