Evaluation of Oxidative Stress Markers in Relation APGAR Scores to in Egyptian Newborns with Intrauterine Growth Retardation

Abstract

The study aimed to estimate the status of oxidative stress markers in neonates of both sexes born 37- 41with intrauterine growth restriction (IUGR) comparing them to healthy convenient for gestational. The study included 44 Egyptian neonates with IUGR of both sexes and 45 neonates of both sexes with appropriate for gestational age. In both groups the neonates were delivered vaginally without any assisted vaginal delivery to mothers without known medical conditions affecting placental sufficiency. Malondialdehyde (MDA, total antioxidant capacity (TAC) and paraoxonase-1(PON1) were measured. Obstetric data including mode of delivery, instrumental delivery and gestational age at delivery by ultrasound Neonatal assessment including gestational age by new Ballard, sex of neonate, weight, head circumference, APGAR score at 1 and 5 minutes, length, full general & systemic examinations of newborn. The activity of MDA was increased, whilelevels of TAC and PON1 were significantly lower in IUGR than controls. APGAR score at both 1 min and 5 min and Ballard were significantly decreased in the IUGR group. Mean birth weight, length, maternal gestational age and head circumference of IUGR cases were decreased than control. APGAR scores were negatively correlated with MDA. In conclusion oxidative stress associated with IUGR newborns and antioxidants during pregnancy may be advised. Oxidative stress markers might have early prediction value for diagnosis of these conditions and probable pharmacological intervention with antioxidants may improve the pregnancy conditions.