Serum 4-Hydroxy-2-nonenal and Induced Nitric Oxide Synthase in Hypertension Patient

Abstract

Hypertension (HT) And related diseases such as chronic kidney disease(CKD) share in that one of the main reasons for them is to increase the oxidative stress, which in turn increases the severity of the disease and exacerbation of symptoms. Reactive molecules produced from oxidative stress, in addition to causing tissue damage by oxidation of biomolecules like DNA, lipids, proteins and sugars; they are lead to the formation of mediators with potent inflammatory effect. The objective of this study was to investigate some markers of oxidative stress in hypertension (HT) and HT with CKD patients in addition to some biochemical parameters related to these diseases. This study involved 84 male subjects aged between (25-65) year equally divided into three groups, first and second one belong to HT and HT with CKD patients respectively from Al-yarmouk Teaching hospital, while the third one for apparently healthy 28 subjects considered as control group. For each subject in the three groups these markers and parameters were evaluated; 4-hydroxy-2-nonenl(4HNE), induced nitric oxide synthase(iNOS), albumin, urea, creatinine ,total serum protein. The results were compared to control; There was a significantly higher (p<0.01) in 4HNE, and iNOS levels in both HT and HT with CKD patients, while serum albumin and Total serum protein shows significantly (p<0.01) lower levels in both groups. The elevation levels of oxidative stress markers may be due to oxidative damage of tissues that caused by these inflammatory diseases. Was concluded that there was a positive relation between oxidation results from these diseases and their developments and suggest increase need to intake of antioxidants as precaution in front of these disease.