Synthesis of Biologically Potent α-Aminophosphonates Derivatives by Nano-Catalyst

Abstract

α-Aminophosphonate and their derivatives are biologically potent and have received considerable attention in a recent research scenario. The main reason is that they show triguing biological activity. α-Aminophosphonate derivatives are gaining a lot of importance in medicinal chemistry due to their application as enzyme inhibitors, herbicides, antibiotics, pharmaceutical agents and inhibitors of Excitatory Post-Synaptic Potential(EPSP) synthesis, and HIV Protease. It is also important in ati-cancer, anti-HIV, antithrombotic and antibacterial, antioxidant activity. Unfortunately, these compounds have certain limitation such as extraction, purification, of bioactive molecule and their minimum yields. For this reason, many scientists have been orienting their research towards the synthesis of molecules as a new tool to overcome this problems he prime focus of this work is the combination of three reactant derivative of benzaldehyde derivative of aniline, and diethyl phosphonate to form α-aminophosphonates derivatives by multicomponent reaction(KFR). The novel nano-catalyst i.e. polyanilinedoped with manganese (PAni-Mn) was prepared. The catalyst shows excellent catalytic activity, high yields, short reaction times, easy synthesis. The PAni was fully characterized by X-ray diffraction, TEM, SEM, and FT-IR technique.