Kinetics and Thermal Decomposition Studies of Oxomemazine by Isoconversional Protocols

Abstract

Thermogravimetry was used to investigate the thermal decomposition of oxomemazine. Oxomemazine has three distinct degradation processes during non-isothermal decomposition. The Arrhenius equation, Coats-Redfern (CR), Horowitz-Metzger (HM), and Flynn-Wall-Ozawa (F-W-O) equations were used in this research to perform kinetic analysis of the first decomposition stage. Oxomemazine thermal stability is very important when it comes to how it can be stored, quality control, and how long it can be used. Using thermal analysis, scientists have been able to learn more about how drug compounds are stable at different temperatures, as well as how fast they break down. Kinetic studies have emerged as a critical component of thermal analysis, with the primary goal of determining the kinetic model of thermal breakdown and calculating the Arrhenius equation parameters. The activation energy of the Arrhenius and Berthelot–Hood temperature functions was determined. The effect of different heating rates (5- 20 oC/min) on thermogravimetric analysis (TG), Differential Thermal Analysis (DTA) is demonstrated.