Synthesis of Azoles in Water by Copper(I)-Catalyzed Prepared by Arc Thermal Plasma Process and a molecular Docking Study Against COVID-19
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Published:2022-10-31
Issue:5
Volume:38
Page:1104-1109
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ISSN:2231-5039
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Container-title:Oriental Journal Of Chemistry
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language:en
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Short-container-title:Orient. J. Chem
Author:
Guesmi Ahlem1ORCID, Khezami Lotfi1ORCID, El-Fattah Wesam Abd1ORCID, Hamadi Naoufel Ben2
Affiliation:
1. 1Chemistry Department, College of Science, IMSIU (Imam Mohammad Ibn Saud Islamic University), P.O. Box 5701, Riyadh 11432, Saudi Arabia. 2. 2Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11ES39), Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5019 Monastir, Tunisia.
Abstract
Huisgen’s 1,3-dipolar cycloadditions in water of 6-azidohexan-1-ol dotted with terminal alkynes and catalyzed with copper nanoparticles, offering access to 1,2,3-triazoles 1,4-disubstituted. The SARS-CoV-2 coronavirus epidemic is still spreading at a fast rate worldwide. The core protease (Mpro) is a gorgeous mark for anti-COVID-19 agents. Click chemistry synthesis, catalyzed using nanoparticles, has been used to prepare the 1,2,3-triazole motif. The high docking score of the newly synthesized triazole are, may be, attributed to the presence of hydrogen bonds together with many interactions between the ligands and the active amino acid residue of the receptor. The comparison of the interactions of Taribavirin and Ribavirin drug with triazole in the largest pocket of 7JWY is also presented. Further interesting comparative docking analyses were performed. The results of this study suggest that triazole 3d may be considered for further investigation as one of the possible therapeutic agents for COVID-19.
Publisher
Oriental Scientific Publishing Company
Subject
Drug Discovery,Environmental Chemistry,Biochemistry,General Chemistry
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