Method Development and Validation for Estimation of Cefadroxil in Different Marketed Tablets by UV Spectrophotometry Method and Anti-Inflammatory Studies Using In-Silico Approaches

Abstract

Quality-based assessment of pharmaceuticals obviates the uncertainties concerning their quality, safety and efficacy for their regulatory purpose. A method was developed and validated for quality control assessment of cefadroxil for the pharmaceuticals or row material analysis. In-silico analysis wasperformedto evaluate the bioavailability, toxicity as well asanti-inflammatory potential of cefadroxil. The results showed that the developed method was found linear, accurate, precise and robust while the dissolution rate of each tablet was found comparable. In-silico docking analysis and network pharmacology analysis showed low bioavailability and toxicity as well as a significant anti-inflammatory potential of cefadroxil via regulation of genes such as TNF-α, IL-6, SLC15A1 and SLC15A2. However, due to its bioavailability barriers, further experimental strategies are necessary to re-purpose the therapeutic application of cefadroxil as a potent anti-inflammatory agent.