One Pot Multicomponent Synthesis of Highly Commutated 1,2,3-Triazoles using some Pyrazole aldehyde through “Click” Reaction

Abstract

1,2,3 Trizole compounds are widely applied in major several technical and research areas especially in drug discovery new chemical entities like trizoles are developed via click reactions. Synthesis of heterocycles through cycloaddition reaction between azides and alkynes by employing and azides using copper as catalyst is said to be Click reaction. Most commonly triazoles are utilized in medicinal field as a drug linkers for bioconjugation. It found to have potential multiple applications in biological as well as medical sciences. We describe herein the novel and efficient three step multicomponent synthesis of highly substituted 1,2,3-triazole derivatives from pyrazole aldehyde, diaminobenzene via N-alkylation by Click reaction.For the future, our perspective is studies of anti-cancer, anti-viral and antimicrobial activities in 1,2,3-triazole.