Thermoanalytical and Kinetic Studies for the Thermal Stability of Nimesulide Under Different Heating Rates

Abstract

The elucidation of the thermal stability and degradation of pharmaceutical drugs utilized in medication is commonly conducted using thermal examination techniques. Kinetic studies have emerged as a critical component of thermal analysis, with the primary goal of determining the kinetic approach of degradation and calculating the Arrhenius equation parameters. The current study describes the thermal behaviour of nimesulide, and the calculation of the melting point using thermoanalytical graphs, as well as the identification of parameters of the decomposition kinetic. The kinetic investigation of nimesulide's active substance's, thermal degradation was carried out in a nitrogen environment via non-isothermal parameters at four rates of heating: 5, 10, 15, 20, and 20 °C/min. The kinetic models of the thermal breakdown pathway were calculated from TG/DTG graphs using differential approaches of Friedman isoconversional method and integral approaches such as the Ozawa, and Starink method.