Hydrothermal Synthesis and Characterization of Yttrium oxide nanoparticles: Bioavailability and Targeting of Breast Tumors

Abstract

Herein, we demonstrate synthesis of Yttrium Oxide (yttria) nanoparticles of 0.1, 0.2, 0.3 and 0.4 M concentrations by hydrothermal method and characterized using various techniques. Powder XRD analysis showed that the as-prepared nanoparticles have cubic Y2O3 structure with an average crystallite diameter of 34-58 nm. SEM micrographs depicted that agglomerated yttria nanoparticles of different morphological properties and particles in size. The occurrence of metal Oxide is affirmed using FTIR and EDX analysis. The Yttrium Oxide nanoparticles showed better antimicrobial activity against ADCP declared harmful bacteria pathogens such as E. Coli, S. paratyphi, S. aureus, and S. pyogenes. Further, the yttrium oxide nanoparticles revealed better anticarcinogenic activity against MCF-7 cell line with IC50 value 47.07 μg/ml. From these findings, the nanoparticles of Y2O3 are candidates to be used as potential alternatives in antitumor therapy.