A Practical Approach for Solubility Enhancement of Albendazole

Abstract

Albendazole is an anti-helmintic or anti-worm medication. Due to its water insolubility, it shows poor absorption in GIT as well as low bioavailability and produces poor therapeutic effect. In this study, various hydrotropic agents are used to enhance the solubility of Albendazole. Addition of 100mg of Albendazole to the 1M Solution of hydrotropic agent like Sodium benzoate, Sodium acetate, Sodium citrate, Sodium salicylate & urea separately and absorbance of each solution at wavelength 306nm was determined. Results shows an increment in solubility of Albendazole and also percentage drug release increased upto 19.8%, 25.9%, 26.5% 73.2%, 75.2%, 76.5% and 80.7% using 1M solution of Sodium benzoate 100ml, Sodium benzoate 50ml, Sodium benzoate +Urea (25ml+25ml), Sodium citrate 50ml, Sodium acetate 50ml, Urea 50ml and Sodium salicylate 50ml respectively. As sodium salicylate has an aromatic ring with an electron donating Hydroxyl group that lacks in other hydrotropic agent used, may be responsible for increase in solubility as well as drug release of Albendazole up to 80.7%.