The DNA-topoisomerase Inhibitors in Cancer Therapy

Author:

Mastrangelo Stefano1,Attina Giorgio1,Triarico Silvia1,Romano Alberto1,Maurizi Palma1,Ruggiero Antonio1

Affiliation:

1. Pediatric Oncology Unit, Fondazione Policlinico Universitario A.Gemelli IRCCS, Universita’ Cattolica Sacro Cuore, Rome, Italy.

Abstract

DNA-topoisomerases are ubiquitous enzymes essential for major cellular processes. In recent years, interest in DNA-topoisomerases has increased not only because of their crucial role in promoting DNA replication and transcription processes, but also because they are the target of numerous active ingredients. The possibility of exploiting for therapeutic purposes the blocking of the activity of these enzymes has led to the development of a new class of anticancer agents capable of inducing apoptosis of tumor cells following DNA damage and its failure to repair.

Publisher

Oriental Scientific Publishing Company

Subject

Pharmacology

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