The DNA-topoisomerase Inhibitors in Cancer Therapy-Reference-Cited by-同舟云学术

The DNA-topoisomerase Inhibitors in Cancer Therapy

Published:2022-06-30 Issue:2 Volume:15 Page:553-562
ISSN:2456-2610
Container-title:Biomedical and Pharmacology Journal
language:en
Short-container-title:Biomed. Pharmacol. J.

Author:

Mastrangelo Stefano¹,Attina Giorgio¹,Triarico Silvia¹,Romano Alberto¹,Maurizi Palma¹,Ruggiero Antonio¹

Affiliation:

1. Pediatric Oncology Unit, Fondazione Policlinico Universitario A.Gemelli IRCCS, Universita’ Cattolica Sacro Cuore, Rome, Italy.

Abstract

DNA-topoisomerases are ubiquitous enzymes essential for major cellular processes. In recent years, interest in DNA-topoisomerases has increased not only because of their crucial role in promoting DNA replication and transcription processes, but also because they are the target of numerous active ingredients. The possibility of exploiting for therapeutic purposes the blocking of the activity of these enzymes has led to the development of a new class of anticancer agents capable of inducing apoptosis of tumor cells following DNA damage and its failure to repair.

Publisher

Oriental Scientific Publishing Company

Subject

Pharmacology

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