Assessment of Dose Dependent Toxicity of Meloxicam in Gallus Domesticus

Abstract

The main objective of the study was to investigate long term use of meloxicam on avian species especially on Gallus domesticus. Animals were divided into 4 groups each having 5 animals. Group I was control and was fed normal diet (maize, grains and millet). Group II was treated with low dose of meloxicam for 15 days. Group III was treated with low dose of meloxicam for 30 days. Group IV was treated with low dose of meloxicam for 60 days. The effect was studied specially on hepatic and renal functions. Meloxicam was given at low dose (0.1 mg/kg body weight) to treatment groups for 15, 30 and 60 days. For biochemical estimation blood and serum were collected by sacrificing animals. Tissues of vital organs were fixed for histological examination. Long term administration of meloxicam cause variation in liver and kidney functioning. No significant change was observed in organ weight of treated groups as compared with control. No significant changes were observed in treated groups as compared to control in hematological parameters, biochemical parameters and lipid profile except SGOT, SGPT and alkaline phosphate in these parameters significant increase was observed. Significant changes were also observed in antioxidant analysis of treated groups as significant increase was observed in LPO and significant decrease in FRAP concentration was observed which signifies the results of histological changes especially in kidney and liver. Changes in histology of treated groups showed effect on kidney and liver as reduction (shrinkage) in glomerulus size and changes in histoarchitecture of central vein in liver of treated group was observed as compared to control group other histological examinations were normal. From results this can be concluded that long term low dose treatment of meloxicam has altered the histoarchitecture of liver and kidney of Gallus domesticus.