Circulating Markers of Adipocytokines levels and BMI in Insulin Resistance Females with Type2 diabetes

Abstract

Background and aim: Obesity is one of the main factors that lead to development of type 2 diabetes mellitus (T2DM), with the prevalence of both increasing worldwide. Obesity is a modifiable risk factor related with many complications and comorbidities. This study aims to evaluate the level of Resistine, Fasting Blood Glucose and Adiponectin compare with the BMI in Insulin Resistance females with Type2 diabetes. Methods: A descriptive cross-sectional - case-control study, the target population is a total 205 Sudanese females were recruited to participate in this study, aged 35-64 years, venous blood samples were collected. Plasma levels of blood glucose were measured using the particle-enhanced immunoturbidimetric assay method Cobas C-311®.While Adiponectin and Resistine estimated by ELISA Kits. Anthropometric measurements, including height and weight, were taken using standard protocols. BMI was calculated as weight (in kilograms) divided by height (in meters squared). Results: Observed from these results significant difference between the means of fasting blood glucose (FBG), adiponectin, esistine and BMI compared with different group classified according to WHO body mass index (BMI) Classification. FBG in underweight (125 ± 15.9), FBG in healthy weight (127 ± 16.7),FBG in overweight (153 ± 19.2) , FBG in obesity (169 ± 20.7), FBG in sever obesity(189 ± 23.7),, P = 0.037, adiponectin in underweight (12.3 ± 1.1),adiponectin in healthy weight (11.2 ± 1.9), adiponectin in overweight (9.7 ± 1.6), adiponectin in obesity (6.1 ±1.5),adiponectin in sever obesity (6.8 ± 1.9), P = 0.043, resistine in underweight (11.6 ± 1.9) , resistine in healthy weight (12.8 ± 1.1), resistine in overweight (14.2 ± 2.7) resistine in obesity (18.2 ± 2.9), resistine in sever obesity (19.1 ± 3.4) , P = 0.021, BMI in underweight(16.5 ± 1.9), BMI in healthy weight (18.3 ± 1.7),BMI in overweight (26.1 ± 2.2),BMI in obesity (30.4 ± 3.7),BMI in sever obesity (40.1 ± 4.0), P = 0.006). In this study, the results show strong negative Correlation between the levels of serum Adiponectin and Fasting Blood Glucose. (P.value = 0.013, r = -7.9), Adiponectin and Resistine. (P.value = 0.019, r = -6.6). In the other side strong positive Correlation between the levels of serum Resistine and Fasting Blood Glucose. (P.value = 0.015, r = 6.0). Observed from this results negative Relationship between the mean of BMI compared with the history of the patient/ years. Conclusion: This study concluded that BMI effected on Adipocytokines levels and Increased risk of insulin resistance in females with Type2 diabetes by increased the level of resistine, fasting blood glucose and reduced of adiponectin in different groups classified according to WHO body mass index (BMI) Classification.