Effect of Sesamol on Arsenic Induced Hepato and Nephrotoxicity in Rats-Reference-Cited by-同舟云学术

Effect of Sesamol on Arsenic Induced Hepato and Nephrotoxicity in Rats

Published:2022-09-29 Issue:3 Volume:15 Page:1361-1368
ISSN:2456-2610
Container-title:Biomedical and Pharmacology Journal
language:en
Short-container-title:Biomed. Pharmacol. J.

Author:

Aldossary Sara A.¹^ORCID,Al-Taher Abdulla²^ORCID

Affiliation:

1. 1Department of pharmaceutical sciences, college of clinical pharmacy, king Faisal university, alahsa, Saudi Arabia.

2. 2Department of biomedical sciences, college of vetenery medicine, king Faisal university, alahsa, Saudi Arabia.

Abstract

Arsenic is considered to be toxic when it is in an inorganic state and basic sources are contamination of water, smoking tobacco and irrigation of food crops. Sesamol is liposoluble lignans extraction that is used in rats to reduce skin papillomas. The main aim of the study is to study the effect of toxic arsenic on rats, usage of sesamol in treating hepato and nephrotoxicity in rats and analyze kidney tissue and liver tissues of the rats. The study primarily focuses on the effect of injecting arsenic and sesamol to the group of animals or injecting both and analyzing them to understand hepatotoxicity and nephrotoxicity. Sesamol along with arsenic powder have been used and the rats were kept in standard condition. The laboratory experiment has been carried out where both single and double oral treatments were provided. Animals were grouped into four groups where every 4 groups have eight rats each. SPPS software has been used to analyze the data collected. It has been shown treated rats with sesamol, counter act the toxicity effect of arsenic upon liver and kidney tissues. It has been found that sesamol has a protective effect upon arsenic induced liver and nephrotoxicity in rats.

Publisher

Oriental Scientific Publishing Company

Subject

Pharmacology

Reference20 articles.

1. 1. Azab, A.E., Albasha, M.O. and Elsayed, A.S.I., 2017. Prevention of nephropathy by some natural sources of antioxidants. Yangtze Medicine, 1(04), p.235.

2. 2. Hasanein, P. and Emamjomeh, A., 2019. Beneficial effects of natural compounds on heavy metal-induced hepatotoxicity. In Dietary Interventions in Liver Disease(pp. 345-355). Academic Press.

3. 3. Kondamudi, P.K., Kovelamudi, H., Mathew, G., Nayak, P.G., Rao, M.C. and Shenoy, R.R., 2014. Investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-induced inflammatory bowel disorder in albino rats. The Scientific World Journal, 2014.

4. 4. Chi, L., Xue, J., Tu, P., Lai, Y., Ru, H. and Lu, K., 2019. Gut microbiome disruption altered the biotransformation and liver toxicity of arsenic in mice. Archives of toxicology, 93(1), pp.25-35.

5. 5. Kumar, N., Mudgal, J., Parihar, V.K., Nayak, P.G., Kutty, N.G. and Rao, C.M., 2013. Sesamol treatment reduces plasma cholesterol and triacylglycerol levels in mouse models of acute and chronic hyperlipidemia. Lipids, 48(6), pp.633-638.